1.
Medchemcomm
; 10(8): 1476-1480, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31673310
RESUMO
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.